Hepatic glycogen

1. Voluntary wheel running increases hepatic glycogen in mice.

   “VWR increased hepatic glycogen content and increased glucagon-stimulated glycogen depletion, regardless of age (P < 0.01).”

   Animalsliver12-wkmales

   Twelve weeks of voluntary wheel running restores glucagon sensitivity in middle-aged mice

   American journal of physiology. Endocrinology and metabolism·6 Jan 2026

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1. Klotho increases hepatic glycogen in mice.

   “Notably, α-Klotho induced striking hepatic glycogen supercompensation through activation of the AKT/GS signaling pathway and upregulation of GLUT4”

   Animalscumulative exercise-induced fatiguemales

   α-Klotho Supplementation Mitigates Cumulative Exercise-Induced Fatigue via Coordinated NRF2-Mediated Antioxidant Defense and AKT/GS-Driven Hepatic Glycogen Supercompensation in Mice

   International journal of molecular sciences·30 Dec 2025

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