Gene expression signatures

Biomarker

2 papers

  • Animals2

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bioRxiv

Simulated microgravity raises transcriptomic age in organoids

Human neural, cardiac, and tonsil organoids exposed to 24 hours of simulated microgravity showed tissue-specific changes, including higher transcriptomic-age estimates in…Human neural, cardiac, and tonsil organoids exposed to 24 hours of simulated microgravity showed tissue-specific changes, including higher transcriptomic-age estimates in brain and heart models.

Preprint: experiments in human cellsMechanisms
bioRxiv

Glymphatic dysfunction is linked to brain aging in schizophrenia

In human imaging and post-mortem brain data, glymphatic impairment occurred in an inflammatory subgroup and tracked with accelerated brain and epigenetic aging.In human imaging and post-mortem brain data, glymphatic impairment occurred in an inflammatory subgroup and tracked with accelerated brain and epigenetic aging.

Preprint: cohort study in peopleMechanisms
Journal of Molecular and Cellular Cardiology

Persistent IFN-γ links to worse cardiac remodeling in aged mice

In 2- and 18-month-old mice of both sexes, elevated interferon-gamma showed little acute impact after myocardial infarction but tracked with aggravated chronic cardiac…In 2- and 18-month-old mice of both sexes, elevated interferon-gamma showed little acute impact after myocardial infarction but tracked with aggravated chronic cardiac remodeling.

Experiments in miceMechanisms