Human neural, cardiac, and tonsil organoids exposed to 24 hours of simulated microgravity showed tissue-specific changes, including higher transcriptomic-age estimates in…Human neural, cardiac, and tonsil organoids exposed to 24 hours of simulated microgravity showed tissue-specific changes, including higher transcriptomic-age estimates in brain and heart models.
In human imaging and post-mortem brain data, glymphatic impairment occurred in an inflammatory subgroup and tracked with accelerated brain and epigenetic aging.In human imaging and post-mortem brain data, glymphatic impairment occurred in an inflammatory subgroup and tracked with accelerated brain and epigenetic aging.
In 2- and 18-month-old mice of both sexes, elevated interferon-gamma showed little acute impact after myocardial infarction but tracked with aggravated chronic cardiac…In 2- and 18-month-old mice of both sexes, elevated interferon-gamma showed little acute impact after myocardial infarction but tracked with aggravated chronic cardiac remodeling.