Ejection fraction
Biomarker3 papers4 findings
- Animals3
Interventions
3Dasatinib + quercetin
upin rats1Very low certainty
1 study
Dasatinib + quercetin
upin rats1Very low certainty
Dasatinib + quercetin improves ejection fraction in rats.
“both treatments improved heart function, with increased ejection fraction and fractional shortening.”
Animalsnormal salt dietheart6 monthsfemalesn = 12
Senolytic treatment with Quercetin and Dasatinib mitigates decline in cardiac function and links heart remodeling to cognitive performance in adult Dahl Salt‐Sensitive Female Rats · AAIC 2025 abstract · 24 Dec 2025
Quercetin
upin rats1Very low certainty
1 study
Quercetin
upin rats1Very low certainty
Quercetin improves ejection fraction in rats.
“both treatments improved heart function, with increased ejection fraction and fractional shortening.”
Animalsnormal salt dietheart100 mg/kgBW/day6 monthsfemalesn = 13
Senolytic treatment with Quercetin and Dasatinib mitigates decline in cardiac function and links heart remodeling to cognitive performance in adult Dahl Salt‐Sensitive Female Rats · AAIC 2025 abstract · 24 Dec 2025
Lactic acid
upin mice1Very low certainty
1 study
Lactic acid
upin mice1Very low certainty
Lactic acid improves ejection fraction in mice.
Animalsin MTKO miceheart
Muscle mTOR Activation Attenuates Cardiomyopathy and Extends Lifespan in Muscle-Specific IRS1/IRS2 Knockout Mice · ADA Scientific Sessions 2025 abstract · 13 Jun 2025
Associations
1Cognitive function
downin humans1
1 study
Cognitive function
downin humans1
Ejection fraction is associated with cognitive function in humans (β=0.033, P=0.013).
Humanspostadjustmentn = 1,592
Cognition and Heart Failure Subtypes: A Large Health Care System Real-World Cohort · Journal of the American Heart Association · 9 Sep 2026
Funding
National Heart, Lung, and Blood InstituteUS$7.2mNational Institute on AgingUS$722.5kVeterans Affairs14 grants since 2022
Veterans AffairsVa Salt Lake City Healthcare System2022–2027
National Institute on AgingMassachusetts General HospitalUS$129.3k2023–2028
National Heart, Lung, and Blood InstituteUniversity of VirginiaUS$786.6k2025–2029
National Heart, Lung, and Blood InstituteUniversity of PennsylvaniaUS$704.6k2024–2029
National Heart, Lung, and Blood InstituteMayo Clinic RochesterUS$1.5m2026–2031
METTL3 in Heart Failure With Preserved Ejection Fraction
National Heart, Lung, and Blood InstituteMassachusetts General HospitalUS$747.3k2026–2030
ECG-AI Based Prediction and Phenotyping of Heart Failure with Preserved Ejection Fraction
National Heart, Lung, and Blood InstituteWake Forest University Health SciencesUS$494.3k2023–2027
PRIME HRrEF: Novel Exercise for Older Patients with Heart Failure with Reduced Ejection Fraction
National Institute on AgingUniversity of VirginiaUS$593.2k2022–2027
National Heart, Lung, and Blood InstituteJohns Hopkins UniversityUS$248.9k2026–2029
National Heart, Lung, and Blood InstituteJohns Hopkins UniversityUS$638.2k2026–2029