Benefits were limited in mice lacking part of an energy-sensing enzyme; researchers compared treated aged mice with untreated young and aged mice.Benefits were limited in mice lacking part of an energy-sensing enzyme; researchers compared treated aged mice with untreated young and aged mice.

Figure from Molecular & Cellular Proteomics

Mouse studyInterventions

Paper

Thursday, October 15

Frontiers in Cardiovascular MedicineOct 15

Pak1 overexpression is associated with mild concentric cardiac remodeling and favorable systolic and diastolic functional indices in transgenic mice

Immunoblot confirmation of cardiac-specific Pak1 transgenic (TG) overexpression and knockout (KO) in mouse hearts.

Experiments in miceExtracellular matrix remodeling

Paper

Friday, October 9

Frontiers in Cardiovascular MedicineOct 9

Vessel lining damage linked to heart dysfunction in Chinese adults

In 503 retired adults in China, each 0.1-micrometer rise in a marker of vessel lining damage was linked to 12% higher odds of asymptomatic heart dysfunction.In 503 retired adults in China, each 0.1-micrometer rise in a marker of vessel lining damage was linked to 12% higher odds of asymptomatic heart dysfunction.

Box plots with overlaid individual data points showing the distribution of PBR values stratified by echocardiographic parameters and diastolic function grades.

Cohort study of 503 peopleLeft ventricular diastolic dysfunction

Paper

Wednesday, October 7

Aging CellOct 7

Exercise or drugs improved heart function in aging mice

A nine-month randomized experiment in 12-month-old mice compared exercise (11 mice), two drugs (15), both (16) and natural aging (12); the interventions improved heart…A nine-month randomized experiment in 12-month-old mice compared exercise (11 mice), two drugs (15), both (16) and natural aging (12); the interventions improved heart performance.

Mice given aerobic exercise, senolytics, or both combined for 9‐months display superior myocardial function to naturally aged mice.

Experiments in miceAerobic exercise

Paper

Tuesday, October 6

Research SquareOct 6

Ventricular-Arterial Coupling in Endurance-Trained Athletes and Sedentary Adults

Preprint: cross-sectional study of 66 peoplePopulations

Paper

Wednesday, September 30

RadiologySep 30

Cardiac MRI diastolic metrics predict heart failure risk

In 59,416 UK Biobank participants, peak early diastolic longitudinal strain rate showed the strongest association with incident heart failure, with a hazard ratio of…In 59,416 UK Biobank participants, peak early diastolic longitudinal strain rate showed the strongest association with incident heart failure, with a hazard ratio of 0.55.

Cohort study of 59,416 peopleHeart failure

Paper

Tuesday, September 29

Journal of Cardiovascular Magnetic ResonanceSep 29

Cardiovascular Magnetic Resonance Reference Values for Left Ventricular Diastolic Function and Left Atrial Sphericity Index in Healthy Adults

Figure from Journal of Cardiovascular Magnetic Resonance

Cross-sectional study of 503 peopleBiomarkers

Paper

Thursday, September 24

Journal of Cardiovascular Development and DiseaseSep 24

Association Between Self-Reported Weekly Physical Activity Duration and Echocardiographic Cardiac Structure and Function in Adults Aged ≥ 45 Years: A Cross-Sectional Study

Participant flow through screening and final analysis.

Cross-sectional study of 84 peoplePopulations

Paper

Wednesday, September 23

Preprints.orgSep 23

Multicentre Cross‑Sectional Study of Left Atrial Strain Imaging as an Early Predictor of Cardiac Dysfunction in Uncontrolled Hypertensive Patients

Preprint: cross-sectional study of 300 peopleCardiac dysfunction

Paper

Friday, September 18

The American Journal of MedicineSep 18

Plant-Based Diets and Prevalent Pre-Heart Failure in the Echocardiographic Study of Latinos (Echo-SOL)

Figure from The American Journal of Medicine

Cross-sectional study of 1,714 peoplePopulations

Paper

Friday, September 11

British Journal of PharmacologySep 11

GPER stimulation attenuates mitochondrial dysfunction and cardiac dysfunction in ovariectomized mice with heart failure with preserved ejection fraction (HFpEF)

Figure from British Journal of Pharmacology

Experiments in miceHeart failure with preserved ejection fraction

Paper

Wednesday, September 9

The Journal of PhysiologySep 9

Early-stage myocardial changes are not aggravated by Western diet or ageing in Mybpc3 c.2373insG heterozygous mice

Experiments in miceMechanisms

Paper

Tuesday, September 8

International Journal of CardiologySep 8

Association of tirzepatide with reverse cardiac remodeling and improved diastolic function in obesity-related HFpEF: A prospective real-world cohort study

Cohort study of 50 peopleTirzepatide

Paper

Friday, September 4

International Journal of Biological SciencesSep 4

Artificial intelligence-assisted reinterpretation of preclinical progeria research suggests a hierarchical nuclear-vascular resilience framework with translational implications

Structured workflow for investigator-led AI-assisted reinterpretation of experimental datasets.

Computational studyProgeria

Paper

Wednesday, August 26

Nursing Edição BrasileiraAug 26

Cardiac Structural Changes Associated With Healthy Aging

Systematic reviewMechanisms

Paper

Monday, August 24

Experimental GerontologyAug 24

Peripheral blood mitochondrial DNA copy number is associated with cardiac diastolic dysfunction in frail older adults

Cohort study of 187 peopleMitochondrial DNA copy number

Paper

Saturday, August 8

International Journal of Heart FailureAug 8

Can Exercise Training Enhance the Functional Capacity and Diastolic Function in Heart Failure With Preserved Ejection Fraction? A Systematic Review and Meta-analysis in the East Asian Population

Meta-analysis of studies in peopleExercise

Paper

Thursday, August 6

Asia Oceania Journal of Nuclear Medicine & BiologyAug 6

Diagnostic performance of gated SPECT myocardial perfusion imaging for early detection of diastolic dysfunction in diabetic patients: A comparative study with echocardiography

Cross-sectional study of 60 peopleLeft ventricular diastolic dysfunction

Paper

Wednesday, August 5

Frontiers in Cardiovascular MedicineAug 5

Long-term SGLT2 inhibitor therapy improves myocardial strain and diastolic function in HFpEF: a retrospective study linking functional recovery to reduced myocardial fibrosis

Cohort study of 185 peopleSGLT2 inhibitors

Paper

Tuesday, August 4

Frontiers in Cardiovascular MedicineAug 4

Effects of HIIT and MICT on cardiovascular function in essential hypertension: roles of inflammation, oxidative stress, and RAS axis

Randomized trial in 56 peopleHigh-intensity interval training

Paper

Sunday, August 2

Cardiovascular Diabetology Endocrinology ReportsAug 2

AI-enabled chest x-ray potentially detects subclinical diastolic dysfunction in diabesity and monitors its functional responses to GLP-1 or GLP-1/GIP receptor agonists: initial exploration and proof-of-concept

Case series of 15 peopleDiastolic dysfunction

Paper

Thursday, July 30

Radiology Cardiothoracic ImagingJul 30

Effects of a Fasting-mimicking Diet on MRI-assessed Cardiac Structure and Function in Participants with Type 2 Diabetes

Randomized trial in 82 peopleType 2 diabetes

Paper

Thursday, July 2

GeroScienceJul 2

Blood fats linked to heart aging in American Indians

Researchers measured 1,542 blood fats twice in 1,801 American Indians, linking several to heart-aging measures and some to later coronary heart disease.Researchers measured 1,542 blood fats twice in 1,801 American Indians, linking several to heart-aging measures and some to later coronary heart disease.

Cohort · 1,801 peopleBiomarkers

Paper