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Cognitive trajectories

Papers on cognitive trajectories

849 papers42 new in 30 days

Friday, November 13

Osteoporosis International

Declining thinking skills linked to higher hip fracture risk

Moderate and rapid cognitive decline were linked to higher fracture risk than high, stable cognition, with hazard ratios—relative risk measures—of 1.39 and 1.86.Moderate and rapid cognitive decline were linked to higher fracture risk than high, stable cognition, with hazard ratios—relative risk measures—of 1.39 and 1.86.

A large thighbone fractured across its neck stands beside a smaller intact thighbone, with small groups of faceless people gathered around them.
Cohort · 14,282 peopleHip fracture
Paper

Monday, November 9

Alzheimer's Research & Therapy

Sleep waves were flatter at later Alzheimer’s disease stages

An observational study linked larger, steeper sleep waves to better cognitive performance over time among people without cognitive impairment.An observational study linked larger, steeper sleep waves to better cognitive performance over time among people without cognitive impairment.

A brain cross-section has deep, broad folds on one side and shallow, close folds on the other, flanked by small groups of upright, faceless people.
Cross-sectional studyAlzheimer's disease
Paper

Sunday, November 8

Friday, November 6

Frontiers in Aging Neuroscience

Coexisting brain and spine diseases linked to worse cognition

Among 100 older adults followed for two years, having both conditions was linked to greater impairment, but not faster decline than either alone.Among 100 older adults followed for two years, having both conditions was linked to greater impairment, but not faster decline than either alone.

Brain sections contrast patchy damage around branching vessels and a compressed neck spinal cord with clear tissue and an uncompressed cord.
Accepted, not yet published: cohort · 100 peopleBiomarkers
Paper

Thursday, November 5

Wednesday, November 4

Research Square

Brain protein’s links to thinking varied across regions

In people below the cutoff for widespread amyloid buildup, an observational study found that some links to thinking abilities varied with brain connections.In people below the cutoff for widespread amyloid buildup, an observational study found that some links to thinking abilities varied with brain connections.

Association between precuneus amyloid burden and cognitive performance in globally amyloid-negative individuals.
Preprint: cohort studyMechanisms
Paper

Tuesday, November 3

Monday, November 2

JAMA Neurology

Delirium linked to later cognitive decline in adults

Delirium was linked to higher relative rates of mild cognitive impairment and dementia, with adjusted hazard ratios of 3.67 and 5.39, respectively, versus no delirium.Delirium was linked to higher relative rates of mild cognitive impairment and dementia, with adjusted hazard ratios of 3.67 and 5.39, respectively, versus no delirium.

Figure from JAMA Neurology
Cohort · 3,501 peopleDelirium
Paper
Research Square

Older adults followed varied paths after mild cognitive impairment

At two years, assessments classified 62.3% of observed participants as cognitively normal, 31.2% as mildly impaired and 6.5% as having dementia.At two years, assessments classified 62.3% of observed participants as cognitively normal, 31.2% as mildly impaired and 6.5% as having dementia.

Change of Cognitive Status From Baseline to Follow up Survey Waves Among Respondents with Initial MCI at Baseline
Preprint: cohort · 6,952 peopleMild cognitive impairment
Paper

Saturday, October 31

Frontiers in Public Health

Persistent minority stress linked to reported cognitive decline

Among 942 sexual and gender minority adults aged 50–76, persistent lifelong exposure was linked to higher odds of reported cognitive decline (adjusted odds ratio 1.50).Among 942 sexual and gender minority adults aged 50–76, persistent lifelong exposure was linked to higher odds of reported cognitive decline (adjusted odds ratio 1.50).

Faceless adults surrounded by dark shapes have fragments in a speech bubble; nearby groups stand in open space beside a bubble with a whole figure.
Accepted, not yet published: cohort · 942 peoplePopulations
Paper

Friday, October 30

Thursday, October 29

Wednesday, October 28

Research Square

Heatwaves linked to faster cognitive aging in Chinese adults

Each additional 10 heatwave days was linked to a steeper age-related decline in cognitive scores, by 0.020 standard deviations per decade.Each additional 10 heatwave days was linked to a steeper age-related decline in cognitive scores, by 0.020 standard deviations per decade.

Heatwave effect on cognitive z-score by age and education.
Preprint: cohort · 13,741 peoplePopulations
Paper

Tuesday, October 27

Monday, October 26

Saturday, October 24

bioRxiv

Gene activity linked to preserved thinking skills in mice

Researchers linked a 271-gene activity pattern to cognitive performance independently of age, including genes involved in building and moving tiny, hairlike cell…Researchers linked a 271-gene activity pattern to cognitive performance independently of age, including genes involved in building and moving tiny, hairlike cell projections.

Behavioral characterization and identification of cognitive heterogeneity across age.
Preprint: cross-sectional studyMechanisms
Paper