Cholesterol accumulation

2 papers2 findings

Animals2

Interventions

2

Polyphenol-rich plant extract

downin mice1

1 study

Polyphenol-rich plant extract decreases cholesterol accumulation in mice.
“reduces adipose accumulation of cholesterol and cholesterol oxides”
Animalsin obese mice fed a high-fat/high-sucrose dietadipose tissue
Healthy adiposity and extended lifespan in obese mice fed a diet supplemented with a polyphenol-rich plant extract
Scientific reports24 Jun 2019

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Hydroxypropyl-beta-cyclodextrin

downin mice1

1 study

Hydroxypropyl-beta-cyclodextrin decreases cholesterol accumulation in mice.
“The reversal of cholesterol accretion by 2-hydroxypropyl-β-cyclodextrin (2-HPC) treatment increased longevity and attenuated behavioral/pathological abnormalities in ANPC mice.”
Animalsin bigenic ANPC mice
Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a β-cyclodextrin
Human molecular genetics6 Aug 2012

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Latest

5 in 12 months

American Journal of Cardiovascular Disease26 Sep

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ReviewInterventions

Frontiers in Nutrition16 Sep

Celery seed extract attenuates sarcopenic obesity and age-related sarcopenia by reducing intramuscular lipid accumulation in mice

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Bioactive Materials29 Aug

A dual-targeting mRNA lipid nanoparticle restores ABCA1-dependent cholesterol homeostasis to promote repair of age-related bone defects

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Journal of Agricultural and Food Chemistry21 Jul

Protective Effects of 18β-Glycyrrhetinic Acid against Inflammaging in Adipose Tissue of Diet-Induced Obese Mice

Experiments in miceInterventions

Mechanisms of Ageing and Development4 Jun

Senolytics ameliorate cognitive decline in D-galactose-induced aging mice by inhibiting astrocytic cholesterol accumulation

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Biomedicine & Pharmacotherapy26 Mar

Rosuvastatin restores liver tissue-resident NK cell activation in aged mice by improving mitochondrial function

Experiments in animalsInterventions

Molecular Neurodegeneration4 Feb

Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD

Experiments in miceCellular senescence

Advanced Science17 Jan

ABCA6 Regulates Chondrogenesis and Inhibits Joint Degeneration via Orchestrated Cholesterol Efflux and Cellular Senescence

Study in peopleMechanisms

Investigative Ophthalmology & Visual Science21 Aug

Cholesterol Accumulation Promotes Photoreceptor Senescence and Retinal Degeneration

Experiments in animalsInterventions

Scientific Reports21 Jun

Elderly mice with history of acetaminophen intoxication display worsened cognitive impairment and persistent elevation of astrocyte and microglia burden

Experiments in animalsMechanisms