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Hydroxypropyl-beta-cyclodextrin

Intervention

2 papers3 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funder: Canadian Institutes of Health Research
  • Animals2

Outcomes

2

Lifespan

upin mice2

2 studies

  1. Hydroxypropyl-beta-cyclodextrin extends lifespan in mice.

    “extended life in the Npc1nmf164 homozygotes but not the transgenic, Npc1nmf164 mice on the BALB/cJ background.”

    Animalsin Npc1nmf164 homozygotes

    In Niemann-Pick C1 mouse models, glial-only expression of the normal gene extends survival much further than do changes in genetic background or treatment with hydroxypropyl-beta-cyclodextrin

    Gene6 Dec 2017

  2. Hydroxypropyl-beta-cyclodextrin extends lifespan in mice.

    “The reversal of cholesterol accretion by 2-hydroxypropyl-β-cyclodextrin (2-HPC) treatment increased longevity and attenuated behavioral/pathological abnormalities in ANPC mice.”

    Animalsin bigenic ANPC mice

    Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a β-cyclodextrin

    Human molecular genetics6 Aug 2012

Cholesterol accumulation

downin mice1

1 study

  1. Hydroxypropyl-beta-cyclodextrin decreases cholesterol accumulation in mice.

    “The reversal of cholesterol accretion by 2-hydroxypropyl-β-cyclodextrin (2-HPC) treatment increased longevity and attenuated behavioral/pathological abnormalities in ANPC mice.”

    Animalsin bigenic ANPC mice

    Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a β-cyclodextrin

    Human molecular genetics6 Aug 2012

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