Caspase-3 expression

1. Caloric restriction showed no clear effect on caspase-3 expression in mice (at 85 weeks, hepatocytes, versus ad libitum feeding) (p=0.34).

   “whereas no significant differences were observed at 85 weeks (p=0.34)”

   Animalsat 85 weeks, hepatocytes, versus ad libitum feedinghepatocytesmales

   Long-term impact of caloric restriction on liver health and cell survival in a mouse model

   Research Square·Sep 21, 2026Preprint

2. Caloric restriction increases caspase-3 expression in mice (at 49 weeks, versus ad libitum feeding) (Kruskal–Wallis p=0.0023; adjusted p=0.0096 versus AL).

   “At 49 weeks, hepatocyte caspase-3 expression was significantly higher in CCR and ICR-RF than in AL”

   Animalsat 49 weeks, versus ad libitum feedingchronic, 25% restrictionhepatocytes25% restrictionmales

   Long-term impact of caloric restriction on liver health and cell survival in a mouse model

   Research Square·Sep 21, 2026Preprint

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1. Resveratrol decreases caspase-3 expression in ovariectomized rats (P = 0.011).

   “Resveratrol decreased mTOR (P = 0.007) and Casp-3 (P = 0.011) expression in chondrocytes”

   Animalsin ovariectomized ratsintravaginal gelchondrocytes0.5 % 0.1 mL, daily28 daysfemales

   Protective effect of vaginal resveratrol administration on joint tissues in ovariectomized rats: Targeting mTOR and сaspase 3

   Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·Jul 20, 2023

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1. Exercise prevents caspase-3 expression in mice (3xTg-AD mice).

   “Expression of caspase 3 (an apoptotic marker) was elevated in 3xTg-AD jejunum and exercise prevented this.”

   Animals3xTg-AD micetreadmill runningjejunum5 days per week5 monthsmales

   Exercise Training Prevents the Loss of Wall Thickness and Lowers Expression of Alzheimer's Related Proteins in 3xTg Mouse Jejunum

   International journal of environmental research and public health·Oct 29, 2022

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