Calpain activity

3 papers2 findings

Humans1
Animals2

Upstream

1

Chiroptera

downin Chiroptera1

1 study

Chiroptera decreases calpain activity in Chiroptera (5-7 fold lower).
“enzyme activity is 5-7 fold lower in bat's brain than in a similar-sized mammal, such as the mouse.”
Animalsbrain
Low levels of calpain activity in Chiroptera brain: implications for mechanisms of aging
Neurobiology of aging1 Jan 1986

More on Chiroptera

Associations

1

Lifespan

downin Mammalia1

1 study

Calpain activity is associated with lifespan in Mammalia.
“maximal life span of bats predicted from the equation relating calpain activity and maximal life span across a wide range of mammals is close to the observed values.”
Animalsbrain
Low levels of calpain activity in Chiroptera brain: implications for mechanisms of aging
Neurobiology of aging1 Jan 1986

Latest

1 in 12 months

Frontiers in Physiology6 May

Methyl eugenol attenuates age-associated oxidative fragility by coupling Ca²⁺-calpain inhibition with Band 3 stabilization in human erythrocytes

Study of 81 peopleInterventions

Biomedicines25 May

Insights into Calpain Activation and Rho-ROCK Signaling in Parkinson's Disease and Aging

ReviewMechanisms

Free Radical Biology & Medicine13 May

PARP1 inhibition prevents oxidative stress in age-related hearing loss via PAR-Ca²⁺-AIF axis in cochlear strial marginal cells

Experiments in animalsMechanisms

Journal of Applied Physiology1 Jul

Skeletal muscle-specific calpastatin overexpression mitigates muscle weakness in aging and extends life span

Experiments in miceMuscle

American Journal of Physiology Heart and Circulatory Physiology25 Feb

Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardium

Experiments in ratsRapamycin

Neurobiology of Aging1 Jan

Low levels of calpain activity in Chiroptera brain: implications for mechanisms of aging

Experiments in miceMechanisms