Bile acid composition

1. Protein restriction is associated with bile acid composition in mice.

   “protein restriction (which inhibits mTORC1) similarly reshaped the BA profile in mice”

   Animalsin mice

   mTORC1-TFEB/TFE3 signaling is associated with bile acid diversification during hepatic metabolic adaptation · Science advances · 25 Sep 2026

Protein restriction →

1. Rapamycin is associated with bile acid composition in mice.

   “shifts toward non-12-OH or 12-OH bile acid species. These effects were attenuated or reversed by Tfe3 deletion or rapamycin treatment.”

   Animalshepatic metabolic adaptationliver

   mTORC1-TFEB/TFE3 signaling is associated with bile acid diversification during hepatic metabolic adaptation · Science advances · 25 Sep 2026

Rapamycin →