National Institute of Neurological Disorders and StrokeUS$2.1mNational Institute on AgingUS$55.1k
National Institute of Neurological Disorders and StrokeUniversity of Texas Hlth Sci Ctr HoustonUS$722.2k2026–2028
Human Dopamine Grafts in Alpha-Synuclein Models of Parkinson Disease
National Institute of Neurological Disorders and StrokeSloan-kettering Inst Can ResearchUS$648.6k2023–2028
The role of alpha-synuclein in nucleolar DNA double-strand break repair and cellular senescence
National Institute on AgingOregon Health & Science UniversityUS$55.1k2023–2027
Changes in Synaptic Vesicle-Binding of Alpha-Synuclein as an Early Biomarker for Synucleinopathies
National Institute of Neurological Disorders and StrokeWeill Medical Coll of Cornell UnivUS$770.7k2024–2029
In mouse midbrain and cultured human neurons, alpha-synuclein pathology led to shorter, more saturated lipid chains, an effect largely reversed in mice by intermittent…In mouse midbrain and cultured human neurons, alpha-synuclein pathology led to shorter, more saturated lipid chains, an effect largely reversed in mice by intermittent fasting.
In mice with severe mitochondrial disease, a two-drug treatment extended median lifespan from 62 days to 158 days.In mice with severe mitochondrial disease, a two-drug treatment extended median lifespan from 62 days to 158 days.
In 18-month-old mice of both sexes exposed to 2% desflurane for two hours, sorafenib pretreatment restored CLOCK protein and improved cognitive performance.In 18-month-old mice of both sexes exposed to 2% desflurane for two hours, sorafenib pretreatment restored CLOCK protein and improved cognitive performance.
Restoring lipid balance through medium-chain triglycerides or fatty acid inhibition protected worms from alpha-synuclein-driven movement deficits.Restoring lipid balance through medium-chain triglycerides or fatty acid inhibition protected worms from alpha-synuclein-driven movement deficits.
Lewy body disease prevalence rose from 0.7% in individuals younger than 50 to 20.0% in those aged 90 and older across 2,480 autopsied human brains.Lewy body disease prevalence rose from 0.7% in individuals younger than 50 to 20.0% in those aged 90 and older across 2,480 autopsied human brains.