What does the research say about macaque?

macaque

There are 8 papers on aging in macaque: 1 observational study in people, 3 in animals, 2 in cells. The newest story, Nov 12, 2026: “Macaque brain aging varies by cell type, region and sex”.

Organism

8 papers study it3 findings

1 new paper in 30 daysSee all 8 papers on macaque

Humans1
Animals3
Cells2
In silico2

Interventions

ASCL1 gene delivery

upMüller glia-specific transgene expression1upneurogenesis1upRGC-like neuron yield1

1 study

ASCL1 gene delivery increases RGC-like neuron yield in macaque cells.
“Regulating ASCL1 expression with microRNA-124 target sites maintained the reprogramming efficiency from adult MG cultures and improved the yield of RGC-like neurons from infant MG cultures.”
Cellsreprogramming cassette incorporating microRNA-124 target sitesMüller glia
Dynamic expression of ASCL1 drives neurogenesis from infant and adult macaque Müller glia into immature retinal ganglion cells
bioRxiv : the preprint server for biologyAug 25, 2025Preprint
ASCL1 gene delivery induces Müller glia-specific transgene expression in macaque cells (mixed primary cultures and intact explant cultures).
“this restricts expression to MG in mixed primary cultures and intact explant cultures of adult macaque retina.”
Cellsmixed primary cultures and intact explant culturesreprogramming cassette incorporating microRNA-124 target sitesretina
Dynamic expression of ASCL1 drives neurogenesis from infant and adult macaque Müller glia into immature retinal ganglion cells
bioRxiv : the preprint server for biologyAug 25, 2025Preprint
ASCL1 gene delivery induces neurogenesis in macaque cells.
“vector-mediated expression of the proneural transcription factor ASCL1 can reprogram adult macaque MG into functional neurons.”
Cellsvector-mediated expressionMüller glia
Dynamic expression of ASCL1 drives neurogenesis from infant and adult macaque Müller glia into immature retinal ganglion cells
bioRxiv : the preprint server for biologyAug 25, 2025Preprint

Latest

3 papers in 12 months

CellNov 12

Macaque brain aging varies by cell type, region and sex

A commentary on macaque brain studies describes context-dependent molecular aging and links to Alzheimer’s disease.A commentary on macaque brain studies describes context-dependent molecular aging and links to Alzheimer’s disease.

Experiments in animalsAI & data