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ASCL1 gene delivery

ASCL1 gene delivery has been studied in 1 paper since 2025: none in people yet, 1 in cells. No study of it in people or animals has been published yet. The newest paper, Aug 25, 2025: “Dynamic expression of ASCL1 drives neurogenesis from infant and adult macaque Müller glia into immature retinal ganglion cells”.

Intervention

1 paper studies it3 findingsUpdated

See all 1 papers on ASCL1 gene delivery

At a glance

The findings reach cells, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

Cells: a single group. Worms or flies, mice and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Cells1

What did studies of ASCL1 gene delivery find?

3

Studies of ASCL1 gene delivery measured 3 outcomes; the most studied are RGC-like neuron yield (1 study), Müller glia-specific transgene expression (1) and neurogenesis (1).

RGC-like neuron yield

upin macaque cells1

1 study

  1. ASCL1 gene delivery increases RGC-like neuron yield in macaque cells.

    “Regulating ASCL1 expression with microRNA-124 target sites maintained the reprogramming efficiency from adult MG cultures and improved the yield of RGC-like neurons from infant MG cultures.”

    Cellsreprogramming cassette incorporating microRNA-124 target sitesMüller glia

    Dynamic expression of ASCL1 drives neurogenesis from infant and adult macaque Müller glia into immature retinal ganglion cells

    bioRxiv : the preprint server for biologyPreprint

Müller glia-specific transgene expression

upin macaque cells1

1 study

  1. ASCL1 gene delivery induces Müller glia-specific transgene expression in macaque cells (mixed primary cultures and intact explant cultures).

    “this restricts expression to MG in mixed primary cultures and intact explant cultures of adult macaque retina.”

    Cellsmixed primary cultures and intact explant culturesreprogramming cassette incorporating microRNA-124 target sitesretina

    Dynamic expression of ASCL1 drives neurogenesis from infant and adult macaque Müller glia into immature retinal ganglion cells

    bioRxiv : the preprint server for biologyPreprint

neurogenesis

upin macaque cells1

1 study

  1. ASCL1 gene delivery induces neurogenesis in macaque cells.

    “vector-mediated expression of the proneural transcription factor ASCL1 can reprogram adult macaque MG into functional neurons.”

    Cellsvector-mediated expressionMüller glia

    Dynamic expression of ASCL1 drives neurogenesis from infant and adult macaque Müller glia into immature retinal ganglion cells

    bioRxiv : the preprint server for biologyPreprint

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