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Yap-activated macrophage-derived exosomes

Yap-activated macrophage-derived exosomes has been studied in 1 paper since 2026: none in people yet, 1 in animals; 1 in the past year. The research so far is in animals. The newest story, Nov 3, 2026: “Immune-cell particles ease bone and muscle decline in aged mice”.

Intervention

1 paper studies it5 findingsUpdated

1 new paper in 30 daysSee all 1 papers on yap-activated macrophage-derived exosomes

At a glance

The findings reach mice, none yet in people. 1 lab.

None of its findings points the other way.

Cells and mice: a single group. Worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab
  • Funders: National Natural Science Foundation of China and 1 more
  • Animals1

What did studies of yap-activated macrophage-derived exosomes find?

5

Studies of yap-activated macrophage-derived exosomes measured 5 outcomes; the most studied are bone and muscle degeneration (1 study), SASP-related inflammatory burden (1) and structural tissue reconstruction and biomechanical recovery (1).

Bone and muscle degeneration

downin mice1

1 study

  1. Yap-activated macrophage-derived exosomes decrease bone and muscle degeneration in mice.

    “Y-M2-EXO reduce the senescence-associated secretory phenotype (SASP)-related inflammatory burden and alleviate bone and muscle degeneration”

    Animalsbone and muscle

    Immune-cell particles ease bone and muscle decline in aged mice

    Journal of nanobiotechnology

SASP-related inflammatory burden

downin mice1

1 study

  1. Yap-activated macrophage-derived exosomes decrease SASP-related inflammatory burden in mice.

    “In naturally aged mice, Y-M2-EXO reduce the senescence-associated secretory phenotype (SASP)-related inflammatory burden”

    Animals

    Immune-cell particles ease bone and muscle decline in aged mice

    Journal of nanobiotechnology

Structural tissue reconstruction and biomechanical recovery

upin rats1

1 study

  1. Yap-activated macrophage-derived exosomes improve structural tissue reconstruction and biomechanical recovery in rats (Achilles tendon rupture and tibial fracture models).

    “hydrogel-delivered Y-M2-EXO ameliorate the injured microenvironment, promote structural tissue reconstruction and biomechanical recovery”

    AnimalsAchilles tendon rupture and tibial fracture modelsROS-responsive hydrogel deliveryAchilles tendon and tibia

    Immune-cell particles ease bone and muscle decline in aged mice

    Journal of nanobiotechnology

osteogenic and tenogenic differentiation

upin cells1

1 study

  1. Yap-activated macrophage-derived exosomes increase osteogenic and tenogenic differentiation in cells (compared with conventional M2 macrophage-derived exosomes).

    “enhancing MSC migration, proliferation, and osteogenic/tenogenic differentiation.”

    Cellscompared with conventional M2 macrophage-derived exosomesmesenchymal stem cell

    Immune-cell particles ease bone and muscle decline in aged mice

    Journal of nanobiotechnology

Oxidative injury

downin cells1

1 study

  1. Yap-activated macrophage-derived exosomes decrease oxidative injury in cells (compared with conventional M2 macrophage-derived exosomes).

    “mitigating oxidative injury and lipid peroxidation-associated cellular damage in mesenchymal stem cells (MSCs)”

    Cellscompared with conventional M2 macrophage-derived exosomesmesenchymal stem cell

    Immune-cell particles ease bone and muscle decline in aged mice

    Journal of nanobiotechnology

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 11 paper in 12 months
Journal of Nanobiotechnology

Immune-cell particles ease bone and muscle decline in aged mice

Experiments in naturally aged mice found benefits from immune-cell particles, with aerobic exercise further improving selected tissue-rebuilding and movement measures.Experiments in naturally aged mice found benefits from immune-cell particles, with aerobic exercise further improving selected tissue-rebuilding and movement measures.

Mouse studyMuscle
Paper

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