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WSTF-ATG8-BLOCKING cell-penetrating peptides

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Against: findings that point the other way from most findings on the same outcome.

  • 1 lab in 1 country
  • 1 finding against
  • Funders: Harvard Catalyst and others
  • Humans1

Outcomes

1

Inflammation

no changein animals1downin animals1

1 study

  1. WSTF-ATG8-BLOCKING cell-penetrating peptides have no effect on inflammation.

    “Cell-penetrating peptides that block the WSTF-ATG8 interaction do not affect acute inflammation”

    Animalsacute inflammation

    WSTF nuclear autophagy regulates chronic but not acute inflammation

    Nature2 Jul 2025

  2. WSTF-ATG8-BLOCKING cell-penetrating peptides decrease inflammation.

    “Cell-penetrating peptides that block the WSTF-ATG8 interaction do not affect acute inflammation but suppress chronic inflammation in senescence as well as in MASH and osteoarthritis”

    Animalsin senescence, MASH, and osteoarthritis

    WSTF nuclear autophagy regulates chronic but not acute inflammation

    Nature2 Jul 2025

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