Verbascoside

2 papers6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: Innovative Research Team of High-level Local University in Shanghai and 1 more

Model organisms1
Cells1

Outcomes

Motility

upin worms1

1 study

Verbascoside improves motility in worms.
“improved healthspan parameters, including motility and resistance to osmotic and thermal stress.”
Model organisms
Verbascoside from Callicarpa nudiflora Hook extends lifespan in Caenorhabditis elegans via SKN-1 pathway activation
Biogerontology9 Dec 2025

Lifespan

upin worms1

1 study

Verbascoside extends lifespan in worms.
“Verbascoside extended the lifespan of C. elegans”
Model organisms
Verbascoside from Callicarpa nudiflora Hook extends lifespan in Caenorhabditis elegans via SKN-1 pathway activation
Biogerontology9 Dec 2025

Cellular senescence

downin human cells1

1 study

Verbascoside inhibits cellular senescence in human cells.
“verbascoside decreased p38 MAPK activation and down-regulated p16, p21, p27, and Rb, thereby attenuating prosenescence signaling and proliferation control.”
Cellsin castration-resistant prostate cancer cells
Verbascoside Suppresses Epithelial-Mesenchymal Transition and Mitochondrial Biogenesis by Targeting Anti-senescence Signaling in Castration-resistant Prostate Cancer
Cancer genomics & proteomics1 Jan 2025