Umbilical cord mesenchymal stem cell-derived exosomes

1. Umbilical cord mesenchymal stem cell-derived exosomes decrease vaginal atrophy in rats.

   “We examined the therapeutic effect of ucMSC-ex injection on vaginal atrophy in ovariectomized rats.”

   Animalsin ovariectomized ratsvaginal tissue

   Regenerative Effect of Vaginal Injections of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Ovariectomized Rats

   Aesthetic plastic surgery·23 Nov 2025

More on Vaginal atrophy

1. Umbilical cord mesenchymal stem cell-derived exosomes decrease inflammation in rats.

   “alleviating the symptoms of GSM by promoting tissue regeneration and vascularization, restoring vaginal lubrication, and reducing inflammation”

   Animalsin ovariectomized ratsvaginal tissue

   Regenerative Effect of Vaginal Injections of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Ovariectomized Rats

   Aesthetic plastic surgery·23 Nov 2025

More on Inflammation

1. Umbilical cord mesenchymal stem cell-derived exosomes increase angiogenesis in rats.

   “ucMSC-ex injection enhanced structural restoration, collagen formation, angiogenesis, estrogen receptor expression, vaginal lubrication, cellular proliferation, and anti-inflammatory response in vaginal tissue”

   Animalsin ovariectomized ratsvaginal tissue

   Regenerative Effect of Vaginal Injections of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Ovariectomized Rats

   Aesthetic plastic surgery·23 Nov 2025

More on Angiogenesis

1. Umbilical cord mesenchymal stem cell-derived exosomes improve vaginal lubrication in rats.

   “ucMSC-ex injection enhanced structural restoration, collagen formation, angiogenesis, estrogen receptor expression, vaginal lubrication, cellular proliferation, and anti-inflammatory response in vaginal tissue”

   Animalsin ovariectomized ratsvaginal tissue

   Regenerative Effect of Vaginal Injections of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Ovariectomized Rats

   Aesthetic plastic surgery·23 Nov 2025

1. Umbilical cord mesenchymal stem cell-derived exosomes improve bone repair in rats.

   “In rat calvarial defect models, UCMSC-Exos treatment resulted in better bone repair in aged rats.”

   Animalscalvarial defect modelcalvarial bone

   Exosomes derived from umbilical cord mesenchymal stem cells alleviate jaw bone marrow mesenchymal stem cells senescence and restore osteogenic differentiation potential

   Stem cell research & therapy·29 Aug 2025

1. Umbilical cord mesenchymal stem cell-derived exosomes activate autophagy in rat cells.

   “Mechanistically, UCMSC-Exos restored autophagy through modulation of the PI3K/AKT/mTOR signaling pathway, as demonstrated by altered protein expression.”

   Cellssenescent cellsjaw bone marrow mesenchymal stem cell

   Exosomes derived from umbilical cord mesenchymal stem cells alleviate jaw bone marrow mesenchymal stem cells senescence and restore osteogenic differentiation potential

   Stem cell research & therapy·29 Aug 2025

More on Autophagy

1. Umbilical cord mesenchymal stem cell-derived exosomes increase osteogenic differentiation potential in rat cells.

   “The exosome-treated cells showed significant improvements in proliferative capacity, migratory ability, and osteogenic differentiation potential compared to untreated controls.”

   Cellssenescent cells; compared to untreated controlsjaw bone marrow mesenchymal stem cell

   Exosomes derived from umbilical cord mesenchymal stem cells alleviate jaw bone marrow mesenchymal stem cells senescence and restore osteogenic differentiation potential

   Stem cell research & therapy·29 Aug 2025

1. Umbilical cord mesenchymal stem cell-derived exosomes decrease cellular senescence in rat cells.

   “UCMSC-Exos treatment markedly attenuated cellular senescence in JBMMSCs”

   Cellssenescent cellsjaw bone marrow mesenchymal stem cell

   Exosomes derived from umbilical cord mesenchymal stem cells alleviate jaw bone marrow mesenchymal stem cells senescence and restore osteogenic differentiation potential

   Stem cell research & therapy·29 Aug 2025

More on Cellular senescence

1. Umbilical cord mesenchymal stem cell-derived exosomes increase NFE2L2 in human cells.

   “resulting in less recognition of YTHDF2 and enhanced stability of Nrf2 expression.”

   Cellsin degenerated nucleus pulposus cellsnucleus pulposus

   MSC-derived exosomes alleviate oxidative stress-induced lysosomal membrane permeabilization damage in degenerated nucleus pulposus cells via promoting m6A demethylation of Nrf2

   Free radical biology & medicine·30 Apr 2025

More on NFE2L2

1. Umbilical cord mesenchymal stem cell-derived exosomes decrease lysosomal membrane permeabilization damage in human cells.

   “umbilical cord derived MSC-Exo inhibited LMP damage in degenerated NPCs by activating Nrf2-medaited anti-oxidative stress effects.”

   Cellsin degenerated human nucleus pulposus cellsnucleus pulposus

   MSC-derived exosomes alleviate oxidative stress-induced lysosomal membrane permeabilization damage in degenerated nucleus pulposus cells via promoting m6A demethylation of Nrf2

   Free radical biology & medicine·30 Apr 2025