Tramiprosate

1. Tramiprosate improves physical function in mice.

   “Histological staining and functional assessments (gait analysis, Basso Mouse Scale, and motor evoked potentials) were conducted to evaluate the therapeutic effects of TMP on SCI.”

   Animalsfollowing spinal cord injury

   Mitochondrial metabolism restoration via Tramiprosate suppresses mitochondrial ROS-driven foamy macrophage senescence post spinal cord injury

   Journal of orthopaedic translation·2 Mar 2026

1. Tramiprosate inhibits cellular senescence in mice.

   “This reduces oxidative damage to nuclear DNA and suppresses the cyclic GMP-AMP synthase (cGAS)-mediated inflammatory response, thereby eliminating senescence in foamy macrophages.”

   Animalsin foamy macrophages post spinal cord injury

   Mitochondrial metabolism restoration via Tramiprosate suppresses mitochondrial ROS-driven foamy macrophage senescence post spinal cord injury

   Journal of orthopaedic translation·2 Mar 2026

More on Cellular senescence

1. Tramiprosate decreases mitochondrial reactive oxygen species in mice.

   “TMP-via upregulation of Shmt2-inhibits mitochondrial reactive oxygen species (mtROS) and mitochondrial DNA (mtDNA) leakage.”

   Animalspost spinal cord injury

   Mitochondrial metabolism restoration via Tramiprosate suppresses mitochondrial ROS-driven foamy macrophage senescence post spinal cord injury

   Journal of orthopaedic translation·2 Mar 2026

More on Mitochondrial reactive oxygen species