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Tetramethyl bisphenol f

Intervention

2 papers5 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: National Key Research and Development Program of China and others
  • Animals1
  • Model organisms1

Outcomes

4

Cellular senescence

upin human cells1upin mice1

1 study

  1. Tetramethyl bisphenol f induces cellular senescence in human cells.

    “sublethal concentrations of TMBPF induced mitochondrial dysfunction, cellular senescence, and disrupted redox homeostasis in GCs in vitro”

    Cellssublethal concentrationsgranulosa cells

    Tetramethyl bisphenol F exposure induces human ovarian granulosa cell senescence and mouse ovarian damage by regulating ESRRB signalling

    Ecotoxicology and environmental safety27 Feb 2025

  2. Tetramethyl bisphenol f induces cellular senescence in mice.

    “TMBPF exposure induced KGN cells senescence and senescent cell accumulation in F1 mouse ovaries by promoting ESRRB/p21 signalling”

    Animalsmaternal exposure from GD7 through PND21ovaryfemales

    Tetramethyl bisphenol F exposure induces human ovarian granulosa cell senescence and mouse ovarian damage by regulating ESRRB signalling

    Ecotoxicology and environmental safety27 Feb 2025

More on Cellular senescence

Ovarian index

downin mice1

1 study

  1. Tetramethyl bisphenol f decreases ovarian index in mice.

    “reducing the ovarian index”

    Animalsmaternal exposure from GD7 through PND21ovary50 μg/kg/day or 200 μg/kg/dayfemales

    Tetramethyl bisphenol F exposure induces human ovarian granulosa cell senescence and mouse ovarian damage by regulating ESRRB signalling

    Ecotoxicology and environmental safety27 Feb 2025

More on Ovarian index

Ovarian fibrosis

upin mice1

1 study

  1. Tetramethyl bisphenol f increases ovarian fibrosis in mice.

    “increasing the number of collagen fibers in the ovarian stroma”

    Animalsmaternal exposure from GD7 through PND21ovarian stroma50 μg/kg/day or 200 μg/kg/dayfemales

    Tetramethyl bisphenol F exposure induces human ovarian granulosa cell senescence and mouse ovarian damage by regulating ESRRB signalling

    Ecotoxicology and environmental safety27 Feb 2025

Mitochondrial reactive oxygen species

upin mammalian cells1

1 study

  1. Tetramethyl bisphenol f increases mitochondrial reactive oxygen species in mammalian cells.

    “Notably, TMBPF was the only bisphenol that caused a significant increase in mitochondrial ROS and mPTP opening.”

    Cellsfibroblast cells

    Comparative toxicities of BPA, BPS, BPF, and TMBPF in the nematode Caenorhabditis elegans and mammalian fibroblast cells

    Toxicology30 Aug 2021

More on Mitochondrial reactive oxygen species

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