INTERACTION OF SPERMIDINE AND A LOW-METHIONINE DIET ON LIFESPAN IN MTDNA-DEFICIENT SACCHAROMYCES CEREVISIAE

Abstract

Spermidine and a low-methionine diet are two strategies shown to extend lifespan in model organisms, such as yeast, worms, flies, and rodents. Mitochondrial dysfunction is one of the theories explaining how organisms age. In previous studies, we used yeast lacking mtDNA (rho0) as a model for mitochondrial dysfunction.