AgingResearch.NewsJoin free

Sirtuin activator

Intervention

6 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: Ministero dell'Università e della Ricerca

Outcomes

4

Neurodegenerative disease

downin reviews1

1 study

  1. Sirtuin activator protects against neurodegenerative disease.

    “Activators show promise in mitigating many age-related diseases such as type 2 diabetes and neurodegeneration.”

    Review

    Sirtuin modulators: a review of patents from 2020 to 2024

    Expert opinion on therapeutic patents4 Nov 2025

More on Neurodegenerative disease

Type 2 diabetes

downin reviews1

1 study

  1. Sirtuin activator protects against type 2 diabetes.

    “Activators show promise in mitigating many age-related diseases such as type 2 diabetes and neurodegeneration.”

    Review

    Sirtuin modulators: a review of patents from 2020 to 2024

    Expert opinion on therapeutic patents4 Nov 2025

More on Type 2 diabetes

Mitochondrial biogenesis (PGC-1α)

upin mice1

1 study

  1. Sirtuin activator increases mitochondrial biogenesis (PGC-1α) in mice.

    “increase the number and activity of mitochondria in obese mice”

    Reviewin obese mice

    Sirtuin activators

    Expert opinion on therapeutic patents1 Apr 2009

More on Mitochondrial biogenesis (PGC-1α)

Response to insulin

upin mice1

1 study

  1. Sirtuin activator improves response to insulin in mice.

    “These improve the response to insulin and increase the number and activity of mitochondria in obese mice.”

    Reviewin obese mice

    Sirtuin activators

    Expert opinion on therapeutic patents1 Apr 2009

Latest

Nov 2025: 1Dec 2025: 2Jan 2026: 1Feb 2026: 0Mar 2026: 1Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 05 in 12 months

Related