Secreted klotho
Secreted klotho has been studied in 1 paper since 2020: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Dec 18, 2020: “Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway”.
1 paper studies it3 findingsUpdated
None of its findings points the other way.
- 1 lab in 1 country
- Funders: National Heart, Lung, and Blood Institute and 1 more
- Animals1
What did studies of Secreted klotho find?
3Studies of Secreted klotho measured 3 outcomes; the most studied are cellular senescence (1 study), cardiac oxidative stress (1) and heart failure (1).
Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
Secreted klotho decreases cellular senescence in mice.
“Secreted Klotho treatment inhibited excessive cardiac oxidative stress, senescence and apoptosis in old mice and KL (-/-) mice.”
Animalsold mice and Klotho-deficient miceexogenous secreted Klothoheart
Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway
Circulation research
Cardiac oxidative stress
downin mice1
1 study
Cardiac oxidative stress
downin mice1
Secreted klotho decreases cardiac oxidative stress in mice.
“Secreted Klotho treatment inhibited excessive cardiac oxidative stress, senescence and apoptosis in old mice and KL (-/-) mice.”
Animalsold mice and Klotho-deficient miceexogenous secreted Klothoheart
Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway
Circulation research
Heart failure
downin mice1
1 study
Heart failure
downin mice1
Secreted klotho prevents heart failure in mice.
“supplement of exogenous secreted Klotho prevented heart failure, hypertrophy, and remodeling in both old mice and KL (-/-) mice.”
Animalsold mice and Klotho-deficient miceexogenous secreted Klothoheart
Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway
Circulation research