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KLOTHODEFICIENCY

Gene

1 paper studies it1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Heart, Lung, and Blood Institute and 1 more
  • Animals1

Effects

1

Heart function

downin mice1

1 study

  1. KLOTHODEFICIENCY impairs heart function in mice.

    “We found that Klotho gene mutation (KL-/-) largely decreased serum klotho levels and impaired heart function.”

    AnimalsKlotho gene mutation (KL-/-)heart

    Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway

    Circulation research

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