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Cardiac-specific GR overexpression

Cardiac-specific GR overexpression has been studied in 1 paper since 2020: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Dec 18, 2020: “Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway”.

InterventionPreclinical

1 paper studies it1 findingUpdated

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Heart, Lung, and Blood Institute and 1 more
  • Animals1

What did studies of Cardiac-specific GR overexpression find?

1

Studies of Cardiac-specific GR overexpression measured 1 outcome; the most studied are heart failure (1 study).

Heart failure

downin mice1

1 study

  1. Cardiac-specific GR overexpression prevents heart failure in mice.

    “Furthermore, cardiac-specific overexpression of GR prevented excessive oxidative stress, apoptosis, and heart failure in both old and KL (-/-) mice.”

    Animalsold and Klotho-deficient micecardiac-specific overexpressionheart

    Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway

    Circulation research

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