Sactriib

1. Sactriib decreases muscle damage in mice.

   “sActRIIB significantly increased muscle fibre size (P < 0.05) in mice subjected to DR and lowered all signs of muscle damage.”

   Animalsin mice subjected to DRmuscle

   Improved health by combining dietary restriction and promoting muscle growth in DNA repair-deficient progeroid mice

   Journal of cachexia, sarcopenia and muscle·8 Sep 2024

1. Sactriib increases muscle fibre size in mice (P < 0.05).

   “sActRIIB significantly increased muscle fibre size (P < 0.05) in mice subjected to DR and lowered all signs of muscle damage.”

   Animalsin mice subjected to DRmuscle

   Improved health by combining dietary restriction and promoting muscle growth in DNA repair-deficient progeroid mice

   Journal of cachexia, sarcopenia and muscle·8 Sep 2024

1. Sactriib increases tetanic force in mice (P < 0.001).

   “with sActRIIB clearly increasing muscle mass (35-65%) and tetanic force (P < 0.001).”

   Animalsin Ercc1Δ/- progeroid micemuscle

   Improved health by combining dietary restriction and promoting muscle growth in DNA repair-deficient progeroid mice

   Journal of cachexia, sarcopenia and muscle·8 Sep 2024

1. Sactriib increases muscle mass in mice (35-65%).

   “with sActRIIB clearly increasing muscle mass (35-65%) and tetanic force (P < 0.001).”

   Animalsin Ercc1Δ/- progeroid micemuscle

   Improved health by combining dietary restriction and promoting muscle growth in DNA repair-deficient progeroid mice

   Journal of cachexia, sarcopenia and muscle·8 Sep 2024

1. Sactriib has no effect on lifespan in mice.

   “The onset of neurological abnormalities was delayed (by ~5 weeks) and their severity reduced, overall sustaining health without affecting lifespan.”

   Animalsin Ercc1Δ/- progeroid mice

   Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling

   Journal of cachexia, sarcopenia and muscle·27 Mar 2019

1. Sactriib decreases urinary protein in mice (4.9 vs. 15.7).

   “there was a major decrease in the protein content in urine (albumin/creatinine of 4.9 sActRIIB treated vs. 15.7 in untreated)”

   Animalsin Ercc1Δ/- progeroid mice

   Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling

   Journal of cachexia, sarcopenia and muscle·27 Mar 2019

More on Urinary protein

1. Sactriib improves muscle activity in mice (5.6 m vs. 13.7 m per hour).

   “sActRIIB-treated progeroid mice maintained muscle activity (distance travel per hour: 5.6 m in untreated mice vs. 13.7 m in treated) and increased specific force”

   Animalsin Ercc1Δ/- progeroid mice

   Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling

   Journal of cachexia, sarcopenia and muscle·27 Mar 2019

1. Sactriib increases hind limb muscle mass in mice (+30-62%).

   “which is largely protected by attenuating myostatin/activin signalling using soluble activin receptor type IIB (sActRIIB) (increase of 30-62% compared with untreated progeric).”

   Animalsin Ercc1Δ/- progeroid mice

   Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling

   Journal of cachexia, sarcopenia and muscle·27 Mar 2019