10 papers2 findings
Epigenetic age
upin humans1
Epigenetic age is associated with morbidity in humans.
“Correlations of epigenetic age with morbidity, mortality and other factors suggest the potential of epigenetic clocks for risk prediction”
Review
Epigenetic clock: A promising biomarker and practical tool in aging
Ageing research reviews4 Oct 2022
DunedinPACE
upin humans1
DunedinPACE is associated with morbidity in humans.
“was associated with morbidity, disability, and mortality”
Humans
DunedinPACE, a DNA methylation biomarker of the pace of aging
eLife14 Jan 2022
6 trialsPhase 444,500 people
1 trialPhase 3384 people
1 trialPhase 2/31,164 people
1 trialPhase 2/32 people
National Institute on AgingUS$671.4kNational Heart, Lung, and Blood InstituteUS$633.6k
Primary Prevention to Reduce Cardiovascular Morbidity and Optimize Cancer Outcomes
National Heart, Lung, and Blood InstituteKaiser Foundation Research InstituteUS$633.6k2022–2027
Aging with HIV: Novel Biomarkers of Inflammation and Morbidity
National Institute on AgingWeill Medical Coll of Cornell UnivUS$194.4k2021–2027
Integrative Multi-Scale Systems Analysis of Gene-Expression-Driven Aging Morbidity
National Institute on AgingNorthwestern UniversityUS$236.9k2020–2026
National Institute on AgingNational Institute on AgingUS$240.1k
In over 109,000 Danish cancer survivors followed for a median 6.9 years, new illness rates exceeded those of cancer-free peers, with short education linked to further…In over 109,000 Danish cancer survivors followed for a median 6.9 years, new illness rates exceeded those of cancer-free peers, with short education linked to further increases.
The mortality hazard ratio was 2.03 for participants with under 5 nanograms per millilitre of vitamin D compared with those with at least 20.The mortality hazard ratio was 2.03 for participants with under 5 nanograms per millilitre of vitamin D compared with those with at least 20.
When researchers applied extra biological age clocks to previously tested anti-aging treatments, no additional clock showed a statistically meaningful effect.When researchers applied extra biological age clocks to previously tested anti-aging treatments, no additional clock showed a statistically meaningful effect.
Across two large health record databases followed for up to a decade, severely low vitamin D was tied to higher mortality, with hazard ratios of 2.57 and 1.59.Across two large health record databases followed for up to a decade, severely low vitamin D was tied to higher mortality, with hazard ratios of 2.57 and 1.59.