Ritonavir

1. Ritonavir extends lifespan in worms.

   “five compounds (all-trans retinoic acid, berberine, fisetin, propranolol, and ritonavir) extended lifespan in Caenorhabditis elegans.”

   Model organisms

   Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes

   eLife·27 Dec 2024Preprint

2. Ritonavir extends lifespan in mice.

   “A modest improvement in lifespan was associated with decreased cardiomyocyte brain natriuretic peptide (BNP) expression”

   Animalsin TG9 mice

   Metabolic and Cardiac Adaptation to Chronic Pharmacologic Blockade of Facilitative Glucose Transport in Murine Dilated Cardiomyopathy and Myocardial Ischemia

   Scientific reports·24 Apr 2018

1. Ritonavir increases cardiac output in mice.

   “Chronic ritonavir also increased cardiac output and dV/dt-d in C57Bl/6 mice following ischemia-reperfusion injury.”

   Animalsfollowing ischemia-reperfusion injuryheart

   Metabolic and Cardiac Adaptation to Chronic Pharmacologic Blockade of Facilitative Glucose Transport in Murine Dilated Cardiomyopathy and Myocardial Ischemia

   Scientific reports·24 Apr 2018

1. Ritonavir improves glucose tolerance in mice.

   “Glucose tolerance was significantly improved with chronic treatment”

   Animalsin TG9 mice

   Metabolic and Cardiac Adaptation to Chronic Pharmacologic Blockade of Facilitative Glucose Transport in Murine Dilated Cardiomyopathy and Myocardial Ischemia

   Scientific reports·24 Apr 2018

1. Ritonavir is associated with age advancement in humans.

   “age advancement in the 2000HIV cohort was positively associated with prior hepatitis C and cytomegalovirus (CMV) infections, non-AIDS-related comorbidities, ART duration, cumulative exposure to the protease inhibitor Ritonavir”

   Humansin PLHIV (2000HIV cohort)

   Plasma Proteomic Signature as a Predictor of Age Advancement in People Living With HIV

   Aging cell·15 Jan 2025

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