Queuine
- 1 lab in 1 country
- Funder: Fundo para o Desenvolvimento das Ciências e da Tecnologia
- Animals1
Outcomes
4Lifespan
upin flies1upin mice1+47% median lifespan
1 study
Lifespan
upin flies1upin mice1+47% median lifespan
Queuine extends lifespan in mice (+15.3% lifespan).
“In naturally aging mice, long-term oral administration extends lifespan by 15.3%”
AnimalsOral administrationLong-term
bioRxiv (Cold Spring Harbor Laboratory)24 Mar 2026Preprint
Queuine extends lifespan in flies (+47% median lifespan).
“In Drosophila, it increases median lifespan by 47% and improves stress resistance and memory.”
Model organisms
bioRxiv (Cold Spring Harbor Laboratory)24 Mar 2026Preprint
Cognitive and motor performance
upin mice1
1 study
Cognitive and motor performance
upin mice1
Queuine improves cognitive and motor performance in mice.
“In naturally aging mice, long-term oral administration extends lifespan by 15.3%, reduces DNA methylation age, improves cognitive and motor performance”
AnimalsOral administrationLong-term
bioRxiv (Cold Spring Harbor Laboratory)24 Mar 2026Preprint
Epigenetic age
downin mice1
1 study
Epigenetic age
downin mice1
Queuine decreases epigenetic age in mice.
“In naturally aging mice, long-term oral administration extends lifespan by 15.3%, reduces DNA methylation age”
AnimalsOral administrationLong-term
bioRxiv (Cold Spring Harbor Laboratory)24 Mar 2026Preprint
Cellular senescence
downin cells1
1 study
Cellular senescence
downin cells1
Queuine decreases cellular senescence in cells.
“Queuine deficiency promotes senescence, whereas supplementation restores manQ levels, improves translational accuracy, suppresses p16/p21-driven senescence programs, and re-establishes proteostatic balance.”
Cells
bioRxiv (Cold Spring Harbor Laboratory)24 Mar 2026Preprint