Mannosyl-queuosine

Mannosyl-queuosine improves translational fidelity in cells.

“Mechanistically, loss of manQ impairs translational fidelity, leading to proteome imbalance, collapse of proteostasis, and aberrant expression of senescence-associated proteins, including GPNMB.”

CellsShown by loss of manQ

Evolutionarily Conserved Decline of tRNA Mannosyl-Queuosine Links Translational Regulation to Aging and Is Reversed by Queuine

bioRxiv (Cold Spring Harbor Laboratory)·24 Mar 2026Preprint