Psychosocial adversity

3 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Gillings School of Public Health and 6 more

Humans2

Outcomes

AgeAccelGrim

upin humans1

1 study

Psychosocial adversity increases AgeAccelGrim in humans (0.91 years (95% CrI: 0.28, 1.53)).
“Per-unit increase in adversity was associated with 0.91 years (95% credible interval [CrI]: 0.28, 1.53; W adulthood = 82%, 95% CrI: 36%, 99%) increased GrimAge acceleration (AgeAccelGrim)”
Humansn = 970
Life-course Psychosocial Adversity and Biological Aging in the Hispanic Community Health Study / Study of Latinos: A Life-course Model Analysis
Research square13 Feb 2026Preprint

Associations

DunedinPACE

upin humans1

1 study

Psychosocial adversity is associated with DunedinPACE in humans (0.013 years/calendar year (95% CrI: -0.005, 0.032)).
“0.013 years/calendar year (95% CrI: -0.005, 0.032; W childhood = 49%, 95% CrI: 3%, 97%; W adulthood = 51%, 95% CrI: 3%, 97%) increased DunedinPACE”
Humansn = 970
Life-course Psychosocial Adversity and Biological Aging in the Hispanic Community Health Study / Study of Latinos: A Life-course Model Analysis
Research square13 Feb 2026Preprint