3 papers5 findings
Major depressive disorder
upin humans1
Major depressive disorder increases AgeAccelGrim in humans (median of 2 years of excess cellular aging, p = 0.001).
“individuals with MDD exhibited significantly greater GrimAge relative to their chronological age ('AgeAccelGrim') compared to healthy controls (p = 0.001)”
Humansunmedicated
"GrimAge," an epigenetic predictor of mortality, is accelerated in major depressive disorder
Translational psychiatry6 Apr 2021
Smoking
downin humans1
Smoking is associated with AgeAccelGrim in humans (β=-0.392, p < 0.001).
“as well as with current non-smoking status (β=-0.392, p < 0.001).”
Humanswithin BD patientsblood
Epigenetic GrimAge acceleration and cognitive impairment in bipolar disorder
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology8 Jul 2022
Cognitive function
downin humans1
AgeAccelGrim is associated with cognitive function in humans (β=-0.088, p = 0.018).
“higher AgeAccelGrim was associated with worse cognitive function in multiple domains (short-term affective memory (β=-0.078, p = 0.030), short-term non-affective memory (β=-0.088, p = 0.018)”
Humanswithin BD patientsblood
Epigenetic GrimAge acceleration and cognitive impairment in bipolar disorder
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology8 Jul 2022
Bipolar disorder
upin humans1
Bipolar disorder is associated with AgeAccelGrim in humans (β=0.197, p = 0.009).
“BD was significantly associated with greater GrimAge acceleration (AgeAccelGrim, β=0.197, p = 0.009)”
Humansblood
Epigenetic GrimAge acceleration and cognitive impairment in bipolar disorder
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology8 Jul 2022
Comorbidity count
upin humans1
AgeAccelGrim is associated with comorbidity count in humans (P=3.45E-17).
“AgeAccelGrim is strongly associated with a host of age-related conditions including comorbidity count (P=3.45E-17)”
Humans
DNA methylation GrimAge strongly predicts lifespan and healthspan
Aging21 Jan 2019
Epigenetic telomere length analysis in patients with sclerosing or biliary cholangitis reveals converging markers of accelerated biological aging.Epigenetic telomere length analysis in patients with sclerosing or biliary cholangitis reveals converging markers of accelerated biological aging.