Pseudoephedrine

1. Pseudoephedrine decreases cellular senescence in human cells.

   “PSE significantly reduced senescent cells, apoptosis rate and P21 level in rat lung tissue and BEAS-2B cells”

   Cellsin cigarette smoke extract-treated BEAS-2B cells

   Pseudoephedrine Improves Chronic Obstructive Pulmonary Disease by Regulating Airway Senescence and Mitochondrial Function through PI3K/AKT/mTOR Axis

   Biomolecules & therapeutics·30 Apr 2026

2. Pseudoephedrine decreases cellular senescence in rats.

   “PSE significantly reduced senescent cells, apoptosis rate and P21 level in rat lung tissue and BEAS-2B cells”

   Animalsin cigarette smoke and LPS-induced COPD modellung

   Pseudoephedrine Improves Chronic Obstructive Pulmonary Disease by Regulating Airway Senescence and Mitochondrial Function through PI3K/AKT/mTOR Axis

   Biomolecules & therapeutics·30 Apr 2026

More on Cellular senescence

1. Pseudoephedrine inhibits PI3K–AKT signalling in rats.

   “PSE markedly suppressed p-p85, p-AKT and p-mTOR protein expressions.”

   Animalsin COPD model

   Pseudoephedrine Improves Chronic Obstructive Pulmonary Disease by Regulating Airway Senescence and Mitochondrial Function through PI3K/AKT/mTOR Axis

   Biomolecules & therapeutics·30 Apr 2026

More on PI3K–AKT signalling

1. Pseudoephedrine improves lung function in rats.

   “PSE also significantly improved lung function in rats”

   Animalsin cigarette smoke and LPS-induced COPD ratslung

   Pseudoephedrine Improves Chronic Obstructive Pulmonary Disease by Regulating Airway Senescence and Mitochondrial Function through PI3K/AKT/mTOR Axis

   Biomolecules & therapeutics·30 Apr 2026