Propionic acid

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funders: Foundation for Food and Agriculture Research and 4 more

Human trial1
Humans1

Outcomes

Cognitive dysfunction

downin mice1

1 study

Propionic acid decreases cognitive dysfunction in mice.
“Oral supplementation of B. pseudolongum or PA mimicked TRF's protective effects”
Animals5xFAD mice
Time-restricted feeding mitigates Alzheimer's disease-associated cognitive impairments via a B. pseudolongum-propionic acid-FFAR3 axis
iMeta21 Feb 2025

Associations

HOMA-IR

upin humans1

1 study

Propionic acid is associated with HOMA-IR in humans (rs = 0.340, p = 0.024).
“and positively with HOMA-IR (rs = 0.340, p = 0.024).”
Humanswith obesity but without diabetes3-day food recordsmalesn = 44
Effect of Food Preservative Propionic Acid on Insulin Resistance
ADA Scientific Sessions 2026 abstract5 Jun 2026