IPA Improves Muscle Function and Reduces Bone Loss in Aged Mice and Modulate Lifespan in Drosophila melanogaster

Abstract

Aging is associated with alterations in endogenous tryptophan (TRP) metabolism that contribute to musculoskeletal decline. In this study, we investigated the effects of the microbiota-derived tryptophan (TRP) metabolite, indole-3-propionic acid (IPA), on musculoskeletal health in aged mice.