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Procyanidin B2

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Key Research and Development Program of Ningxia and 2 more
  • Cells1

Outcomes

1

Cellular senescence

downin mouse cells1

1 study

  1. Procyanidin B2 decreases cellular senescence in mouse cells.

    “senescent granulosa cells were treated with procyanidin B2 (PCB2), which has anti-inflammatory effects, and the TFAM-mediated mtDNA-cGAS-STING pathway was inhibited, accompanied by a markedly reduced SASP phenotype and granulosa cell senescence.”

    Cellssenescent granulosa cellsgranulosa cell

    Immp2l gene knockout induces granulosa cell senescence by activation of cGAS-STING pathway via TFAM-mediated mtDNA leakage

    International journal of biological macromolecules20 Mar 2025

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