PLXDC2
GeneHomo sapiens1 paper1 findingHGNC 21013NCBI Gene 84898Taxon 9606
- Animals1
Associations
1Parkinson's disease
upin silico1
1 study
Parkinson's disease
upin silico1
PLXDC2 is associated with Parkinson's disease in silico.
“By constructing the largest-to-date single-cell atlas of the human substantia nigra, we identified a marked upregulation of PLXDC2 in PD microglia.”
In silicoin PD microgliasubstantia nigra
Targeted nanoplatform reduces microglial senescence and eases motor deficits in Parkinson mice · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026
Latest
1AnimalsCellular senescence
Targeted nanoplatform reduces microglial senescence and eases motor deficits in Parkinson mice
Silencing the upregulated gene PLXDC2 via brain-penetrating nanoparticles suppressed cGAS-STING signaling, reduced iron accumulation, and protected dopaminergic neurons.