Pirfenidone
- 3 independent labs in 3 countries
- 5 trials, 3 about aging
- Funders: European Regional Development Fund and 8 more
- 2 of 5 trials sponsored by its developers
- Humans1
- Animals3
- Cells2
Outcomes
10COL1A1
downin mouse cells2
2 studies
COL1A1
downin mouse cells2
Pirfenidone decreases COL1A1 in mouse cells.
“Pirfenidone significantly reduced Col1a1 expression.”
Cellstreated with a pro-fibrotic or a pro-inflammatory stimulusovary
Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse
GeroScienceSep 16, 2024
Pirfenidone decreases COL1A1 in mouse cells.
“Pirfenidone significantly reduced Col1a1 expression.”
Cellsin ovarian stromal cells
Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse
bioRxiv : the preprint server for biologyJun 25, 2024Preprint
Ovarian function
upin mice2
2 studies
Ovarian function
upin mice2
Pirfenidone improves ovarian function in mice.
“Ovarian function was improved in Pirfenidone-treated mice as evidenced by increased follicle and corpora lutea number, AMH levels, and improved estrous cyclicity.”
Animalsmini-osmotic pumpsovary6 weeksfemales
Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse
GeroScienceSep 16, 2024
Pirfenidone improves ovarian function in mice.
“Ovarian function was improved in Pirfenidone-treated mice as evidenced by increased follicle and corpora lutea number, AMH levels, and improved estrous cyclicity.”
Animalsmini-osmotic pumpsovary6-weeks
Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse
bioRxiv : the preprint server for biologyJun 25, 2024Preprint
profibrotic programs
downin humans1
1 study
profibrotic programs
downin humans1
Pirfenidone inhibits profibrotic programs in humans.
“CD8+/CD4 + T cells, lymphoid endothelial cells and dendritic cells”
Reviewin fILD
Bridging the Gap: The Emerging Role of memory CD8+ T Cells in Fibrotic Interstitial Lung Disease
American journal of respiratory cell and molecular biologyJun 19, 2026
Ovarian fibrosis
downin mice1
1 study
Ovarian fibrosis
downin mice1
Pirfenidone decreases ovarian fibrosis in mice.
“Pirfenidone mitigated the age-dependent increase in ovarian fibrosis without impacting overall health parameters.”
Animalsmini-osmotic pumpsovary6 weeksfemales
Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse
GeroScienceSep 16, 2024
Extracellular matrix remodelling
downin mice1
1 study
Extracellular matrix remodelling
downin mice1
Pirfenidone decreases extracellular matrix remodelling in mice.
“Pirfenidone mitigated the age-dependent increase in ovarian fibrosis without impacting overall health parameters.”
Animalsmini-osmotic pumpsovary6-weeks
Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse
bioRxiv : the preprint server for biologyJun 25, 2024Preprint
MAPK/ERK signalling
downin human cells1
1 study
MAPK/ERK signalling
downin human cells1
Pirfenidone inhibits MAPK/ERK signalling in human cells.
“PFD and NTD only inhibited ERK1/2 phosphorylation”
Cellsinduced by IL-11
European journal of pharmacologyMar 30, 2024
Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
Pirfenidone inhibits cellular senescence in human cells.
“inhibitory effect of PFD and NTD on IL-11-induced endothelial and muscle cells proliferation and senescence”
CellsIL-11-induced
European journal of pharmacologyMar 30, 2024
endothelial-to-mesenchymal transition
downin human cells1
1 study
endothelial-to-mesenchymal transition
downin human cells1
Pirfenidone decreases endothelial-to-mesenchymal transition in human cells.
“nintedanib (NTD) and pirfenidone (PFD) ameliorates endothelial to mesenchymal transition (EnMT)”
Cellsinduced by IL-11
European journal of pharmacologyMar 30, 2024
Ovulation
upin mice1
1 study
Ovulation
upin mice1
Pirfenidone improves ovulation in mice.
“antifibrosis drugs (pirfenidone and BGP-15) eliminate fibrotic collagen and restore ovulation in reproductively old and obese mice”
Animalsin reproductively old and obese miceovaryfemales
Science advancesJun 17, 2022
Fibrotic collagen
downin mice1
1 study
Fibrotic collagen
downin mice1
Pirfenidone decreases fibrotic collagen in mice.
“antifibrosis drugs (pirfenidone and BGP-15) eliminate fibrotic collagen and restore ovulation in reproductively old and obese mice”
Animalsin reproductively old and obese miceovaryfemales
Science advancesJun 17, 2022
Trials
3 about aging, of 5About aging
Phase 1/2Recruiting
An Extension Study of Subjects Who Received an Avalyn Inhaled Antifibrotic Agent (SAIL)
Phase 2Recruiting
Phase 2Active, not recruiting
Development
- Companies
- Avalyn PharmaPhase 2pulmonary fibrosis, progressive pulmonary fibrosis
Trial sponsors
Company2 trialsPhase 2738 people
National Institute of Allergy and Infectious Diseases
1 trialPhase 1/2250 people