Physiological oxygen concentration

1 paper1 finding

1 lab in 1 country

Funders: Dr. Miriam and Sheldon G. Adelson Medical Research Foundation and 1 more

Cells1

Outcomes

1

Proliferative lifespan

upin human cells1

1 study

Physiological oxygen concentration increases proliferative lifespan in human cells.
“reducing oxygen concentration to a physiological level range (3%) dramatically extends the proliferative lifespan of human A-T skin fibroblasts.”
Cellsataxia-telangiectasiaskin fibroblast3% oxygen versus 21%
Accelerated replicative senescence of ataxia-telangiectasia skin fibroblasts is retained at physiologic oxygen levels, with unique and common transcriptional patterns
Aging cell30 May 2023

Latest

Aging Cell31 May

Accelerated replicative senescence of ataxia-telangiectasia skin fibroblasts is retained at physiologic oxygen levels, with unique and common transcriptional patterns

Experiments in human cellsCellular senescence