Ataxia telangiectasia

2 papers1 finding

Animals1
Cells1

Interventions

1

NAD+ precursors

downin mice1

1 study

NAD+ precursors decrease ataxia telangiectasia in mice.
Animalsin ATM-deficient animals
NAD⁺ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
Cell metabolism11 Oct 2016

More on NAD+ precursors

Trial sponsors

Quince Therapeutics
Company2 trialsPhase 3206 people
NHS Tayside
1 trialPhase 427 people
Johann Wolfgang Goethe University Hospital
1 trialPhase 424 people
Radboud University Medical Center
1 trialPhase 224 people
University Hospital, Akershus
1 trialPhase 213 people
Sara Elva Espinosa Padilla, MD
1 trialPhase 26 people

Funding

1 grant since 2025

National Institute of Neurological Disorders and StrokeUS$69.5k

Single-Cell Analysis of Somatic Mutation Rates, Mechanisms, and Impacts in Human Ataxia Telangiectasia Cerebellum
National Institute of Neurological Disorders and StrokeUniv of Massachusetts Med Sch WorcesterUS$35k2025–2028

Latest

2 in 12 months

Antioxidants & Redox SignalingYesterday

Immune Checkpoint Inhibitor-Induced Cardiovascular Disease: The Role of Accelerated Senescence in Vascular Dysfunction

ReviewImmune response

Aging Medicine (Milton (N.S.W))6 Sep

Insights Into the Mechanisms of Biological Aging That Guide Translational and Clinical Research

CommentaryMechanisms

Science Advances25 Oct

Mitochondrial fatty acid oxidation drives senescence

Experiments in animalsFatty acid β-oxidation

International Journal of Molecular Sciences17 Dec

Dapagliflozin Prevents High-Glucose-Induced Cellular Senescence in Renal Tubular Epithelial Cells

Experiments in human cellsDapagliflozin

Cell Metabolism11 Oct

NAD⁺ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

Experiments in miceInterventions

Cell8 May

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction

Experiments in wormsInterventions

Nature30 Nov

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Experiments in miceDNA damage response

Current Biology2 Sep

DNA damage foci at dysfunctional telomeres

Experiments in human cellsTelomerase and telomere maintenance