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Pharmacological complementation of P21 function

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

Outcomes

1

Aortic aneurysm and dissection

downin mice1

1 study

  1. Pharmacological complementation of P21 function decreases aortic aneurysm and dissection in mice.

    “Finally, both pharmacological complementation of P21 function and knockdown of STING expression alleviated ATF3 deficiency-induced AAD.”

    AnimalsATF3 deficiencyaorta

    Deficiency of ATF3 facilitates both angiotensin II-induced and spontaneously formed aortic aneurysm and dissection development by activating cGAS-STING pathway

    Clinical and translational medicine28 Dec 2024

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