Perinatal HIV exposure without infection

1. Perinatal HIV exposure without infection increases Framingham 30-year risk of cardiovascular disease in humans (9.7% vs. 5.8%).

   “These differences conferred a higher metabolic comorbidity score (1.5±1.4 vs. 0.3±0.7, P<0.001) and 30-year CVD risk (9.7% vs. 5.8%, P=0.02).”

   Humansmatched controls

   MON-696 Obesity and Metabolic Comorbidities in Young Adults with Perinatal HIV Exposure Without Infection

   ENDO 2025 abstract·22 Oct 2025

More on Framingham 30-year risk of cardiovascular disease

1. Perinatal HIV exposure without infection raises the risk of hepatic steatosis in humans (44% vs. 15%).

   “dyslipidemia (46% vs. 15%, P=0.002), and hepatic steatosis (44% vs. 15%, P=0.006) compared to matched controls.”

   Humansmatched controls

   MON-696 Obesity and Metabolic Comorbidities in Young Adults with Perinatal HIV Exposure Without Infection

   ENDO 2025 abstract·22 Oct 2025

More on Hepatic steatosis

1. Perinatal HIV exposure without infection raises the risk of hypertension in humans (20% vs. 0%).

   “impaired glucose tolerance (21% vs. 3%, P=0.01), insulin resistance (24% vs. 2%, P=0.004), hypertension (20% vs. 0%, P=0.003), dyslipidemia (46% vs. 15%, P=0.002)”

   Humansmatched controls

   MON-696 Obesity and Metabolic Comorbidities in Young Adults with Perinatal HIV Exposure Without Infection

   ENDO 2025 abstract·22 Oct 2025

More on Hypertension

1. Perinatal HIV exposure without infection raises the risk of obesity in humans (51% vs. 29%).

   “Young adults with PHEU (24±5 y, 46% male) had higher rates of obesity (51% vs. 29%, P=0.04)”

   Humansmatched controls

   MON-696 Obesity and Metabolic Comorbidities in Young Adults with Perinatal HIV Exposure Without Infection

   ENDO 2025 abstract·22 Oct 2025

More on Obesity