Substance use disorders

Disease

3 papers1 finding

  • Humans2

Associations

1

AgeAccelGrim2

upin humans1

1 study
  1. Substance use disorders are associated with AgeAccelGrim2 in humans (β=0.061, p=6.608e-06).

    Humansn = 2,276

    Substance use and epigenetic age acceleration: Associations with alcohol, tobacco, illicit drugs, and SUD severity

    Drug and alcohol dependence5 Aug 2026

More on AgeAccelGrim2

Trial sponsors

Funding

2 grants since 2022

National Institute of Mental HealthUS$2mNational Institute on Drug AbuseUS$1.4m

Latest

Nov 2025: 1Dec 2025: 2Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 2Sep 2026: 1Oct 2026: 410 in 12 months
Psychological Medicine

Brain age estimates were higher across six disorders

The gap between scan-estimated and actual age exceeded age-matched controls by 7.64 years in schizophrenia and 7.61 years in frontotemporal dementia.The gap between scan-estimated and actual age exceeded age-matched controls by 7.64 years in schizophrenia and 7.61 years in frontotemporal dementia.

Cross-sectional study of 25,425 peopleBiomarkers