PAI-1 inhibitors

1. PAI-1 inhibitors have no effect on doxorubicin cytotoxicity in mouse cells.

   “Notably, PAI-1 inhibition did not attenuate Dox cytotoxicity in EO771 murine breast cancer cells.”

   Cellsdoxorubicin-treated murine breast cancer cellsEO771

   Inhibition of PAI-1 shifts cardiomyocyte fate from senescence toward apoptosis and mitigates doxorubicin-induced cardiotoxicity

   Geromedicine·17 Mar 2026

1. PAI-1 inhibitors protect against cardiac structure and function in mice.

   “Pharmacological inhibition of PAI-1 reduced senescence markers, enhanced apoptotic responses, and preserved cardiac structure and function in Dox-treated mice.”

   Animalsdoxorubicin-treated miceheart

   Inhibition of PAI-1 shifts cardiomyocyte fate from senescence toward apoptosis and mitigates doxorubicin-induced cardiotoxicity

   Geromedicine·17 Mar 2026

1. PAI-1 inhibitors increase apoptosis in mice.

   “Pharmacological inhibition of PAI-1 reduced senescence markers, enhanced apoptotic responses, and preserved cardiac structure and function in Dox-treated mice.”

   Animalsdoxorubicin-treated miceheart

   Inhibition of PAI-1 shifts cardiomyocyte fate from senescence toward apoptosis and mitigates doxorubicin-induced cardiotoxicity

   Geromedicine·17 Mar 2026

More on Apoptosis

1. PAI-1 inhibitors decrease P21-HIGH senescent cardiomyocyte count in mice.

   “Fate mapping analyses with p21 High -tdTomato mice revealed that PAI-1 inhibition decreased the number of p21 High senescent cardiomyocytes in Dox-treated hearts.”

   Animalsdoxorubicin-treated p21 High -tdTomato reporter miceheart

   Inhibition of PAI-1 shifts cardiomyocyte fate from senescence toward apoptosis and mitigates doxorubicin-induced cardiotoxicity

   Geromedicine·17 Mar 2026

More on P21-HIGH senescent cardiomyocyte count