P21-HIGH senescent cardiomyocyte count

1 paper1 finding

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PAI-1 inhibitors

downin mice1

1 study

PAI-1 inhibitors decrease P21-HIGH senescent cardiomyocyte count in mice.
“Fate mapping analyses with p21 High -tdTomato mice revealed that PAI-1 inhibition decreased the number of p21 High senescent cardiomyocytes in Dox-treated hearts.”
Animalsdoxorubicin-treated p21 High -tdTomato reporter miceheart
Inhibition of PAI-1 shifts cardiomyocyte fate from senescence toward apoptosis and mitigates doxorubicin-induced cardiotoxicity
Geromedicine17 Mar 2026

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Geromedicine17 Mar

Inhibition of PAI-1 shifts cardiomyocyte fate from senescence toward apoptosis and mitigates doxorubicin-induced cardiotoxicity

Experiments in miceApoptosis