Oxygen

3 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: National Institute on Aging and 5 more

Animals2
Cells1

Outcomes

QTc interval

upin mice1

1 study

Oxygen increases QTc interval in mice (QTc 57.2 ± 1.8 ms to 78.4 ± 2.5 ms).
“A significant electrical remodeling (QTc 57.2 ± 1.8 ms to 78.4 ± 2.5 ms) was also observed.”
Animalsend-of-life care model70% O272 h
Supplemental oxygen induced cardiovascular pathophysiology in an end-of-life care model in mice
Physiological reports1 Aug 2026

Cardiac output

downin mice1

1 study

Oxygen decreases cardiac output in mice (38.2 ± 1.5 mL/min to 12.8 ± 1.2 mL/min).
“cardiac output (38.2 ± 1.5 mL/min to 12.8 ± 1.2 mL/min in males and 8.1 ± 0.9 mL/min in females)”
Animalsend-of-life care model70% O272 hmales
Supplemental oxygen induced cardiovascular pathophysiology in an end-of-life care model in mice
Physiological reports1 Aug 2026

Ejection fraction

downin mice1

1 study

Oxygen decreases ejection fraction in mice (82.5% ± 2.1% to 59.8% ± 3.4%).
“Exposure to 70% O2 led to significant reduction in ejection fraction (82.5% ± 2.1% to 59.8% ± 3.4%)”
Animalsend-of-life care model70% O272 h
Supplemental oxygen induced cardiovascular pathophysiology in an end-of-life care model in mice
Physiological reports1 Aug 2026