Osteopontin

Intervention

2 papers5 findings

MeSH

  • 2 independent labs in 2 countries
  • Funders: Australian Research Council and 8 more
  • Animals1
  • Cells1

Outcomes

4

Hair growth

upin human cells1upin mice1

1 study
  1. Osteopontin induces hair growth in human cells.

    “it stimulates new growth of human hair follicles”

    Cells

    Signalling by senescent melanocytes hyperactivates hair growth

    NatureJun 21, 2023

  2. Osteopontin induces hair growth in mice.

    “Injection of osteopontin or its genetic overexpression is sufficient to induce robust hair growth in mice”

    Animals

    Signalling by senescent melanocytes hyperactivates hair growth

    NatureJun 21, 2023

Trophic effects on human osteoblasts

upin human cells1

1 study
  1. Osteopontin improves trophic effects on human osteoblasts in human cells.

    “The conditioned medium from P10 ASCs on OPN-coating improved trophic effects on HOBs.”

    Cellsconditioned medium from P10 ASCs on OPN-coating

    Osteopontin Rejuvenates Senescent Adipose-Derived Stem Cells and Restores their Bone Tissue Regenerative Function

    Stem cell reviews and reportsMar 12, 2024

Stem cell differentiation

upin human cells1

1 study
  1. Osteopontin increases stem cell differentiation in human cells.

    “P10 ASCs on OPN-coated surface showed rejuvenated phenotype and enhanced osteogenic differentiation.”

    CellsP10 senescent ASCsOPN-coated surfaceadipose-derived mesenchymal stem cells

    Osteopontin Rejuvenates Senescent Adipose-Derived Stem Cells and Restores their Bone Tissue Regenerative Function

    Stem cell reviews and reportsMar 12, 2024

More on Stem cell differentiation

Cellular senescence

downin human cells1

1 study
  1. Osteopontin decreases cellular senescence in human cells.

    “P10 ASCs on OPN-coated surface showed rejuvenated phenotype and enhanced osteogenic differentiation.”

    CellsP10 senescent ASCsOPN-coated surfaceadipose-derived mesenchymal stem cells

    Osteopontin Rejuvenates Senescent Adipose-Derived Stem Cells and Restores their Bone Tissue Regenerative Function

    Stem cell reviews and reportsMar 12, 2024

More on Cellular senescence

Funding

2 grants since 2020

National Eye InstituteUS$1.8mJapan Society for the Promotion of ScienceJP¥4.3m

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