AgingResearch.NewsJoin free

Oral microbiota

Oral microbiota has been studied in 4 papers since 2024: 2 observational studies in people, 2 reviews; 2 in the past year. The newest story, Oct 27, 2026: “Oral microbes linked to brain structure in adults”.

Exposure

4 papers study it4 findingsUpdated

1 new paper in 30 daysSee all 4

“87 associations involving 51 taxa and 79 traits passed Benjamini-Hochberg correction across taxa within each imaging-derived phenotype.”
Integrated Genetic and Multi-Omic Analyses Reveal Oral Microbial Associations with Brain Structure and Alzheimer's DiseaseMicroorganisms2026doi:10.3390/microorganisms14102157

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 1 country
  • Funders: Chongqing Municipal Education Commission and 7 more
  • Humans2

What is Oral microbiota linked with?

4

Studies link Oral microbiota with 4 measures, most often Alzheimer's disease (1 study), brain imaging-derived phenotypes (1) and cardiovascular disease (1).

Alzheimer's disease

mixedin humans1

1 study

  1. Oral microbiota is associated with Alzheimer's disease in humans (nominal genetic associations) (35 taxa).

    “In total, 35 taxa showed nominal genetic associations with Alzheimer's disease.”

    Humansnominal genetic associations

    Oral microbes linked to brain structure in adults

    Microorganisms

More on Alzheimer's disease

Brain imaging-derived phenotypes

mixedin humans1

1 study

  1. Oral microbiota is associated with brain imaging-derived phenotypes in humans (two-sample Mendelian randomization) (87 associations involving 51 taxa and 79 traits).

    “87 associations involving 51 taxa and 79 traits passed Benjamini-Hochberg correction across taxa within each imaging-derived phenotype.”

    Humanstwo-sample Mendelian randomizationbrain

    Oral microbes linked to brain structure in adults

    Microorganisms

Cardiovascular disease

upin humans1

1 study

  1. Oral microbiota is associated with cardiovascular disease in humans (10 positive (risk factors) and 7 negative (protective factors) causative directions).

    “The MR analysis identified suggestive associations between specific oral bacteria and cardiovascular diseases, including 10 positive (risk factors) and 7 negative (protective factors) causative directions.”

    Humans

    Oral Microbiota and Cardiovascular Diseases: A Study Integrating Genome-Wide Association and 16S rRNA Sequence Analyses

    International dental journal

More on Cardiovascular disease

Neurodegenerative disease

upin humans1

1 study

  1. Oral microbiota is associated with neurodegenerative disease in humans.

    “clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases”

    Review

    Unraveling brain aging through the lens of oral microbiota

    Neural regeneration research

More on Neurodegenerative disease

Funding

3 grants since 2023

Japan Society for the Promotion of ScienceJP¥44.6mWellcome Trust£864.2k

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 1Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 1Oct 2026: 02 papers in 12 months
Microorganisms

Oral microbes linked to brain structure in adults

The genetic analysis found 87 associations linking 51 types of oral microbes to 79 brain scan measures in adults.The genetic analysis found 87 associations linking 51 types of oral microbes to 79 brain scan measures in adults.

Mendelian randomizationAI & data
Paper

Related