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Nortriptyline

Intervention

2 papers3 findings

PubChemChEBIMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: National Natural Science Foundation of China and 2 more
  • Animals2

Outcomes

3

Gastric cancer

downin humans1

1 study

  1. Nortriptyline decreases gastric cancer in humans.

    “Nor administration attenuates lysosomal exocytosis-mediated senescence-associated secretory phenotype (SASP) and reduces aggressive phenotypes in gastric cancer models”

    Animalsin gastric cancer models

    Nortriptyline Inhibits Lysosomal Exocytosis-Mediated SASP During Gastric Cancer Progression via Targeting HOXA1-PITX2 Phase Separation

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)25 Sep 2025

More on Gastric cancer

Senescence-associated secretory phenotype (SASP)

downin humans1

1 study

  1. Nortriptyline inhibits senescence-associated secretory phenotype (SASP) in humans.

    “Nor administration attenuates lysosomal exocytosis-mediated senescence-associated secretory phenotype (SASP)”

    Animalsin gastric cancer models

    Nortriptyline Inhibits Lysosomal Exocytosis-Mediated SASP During Gastric Cancer Progression via Targeting HOXA1-PITX2 Phase Separation

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)25 Sep 2025

More on Senescence-associated secretory phenotype (SASP)

Lifespan

upin mice1

1 study

  1. Nortriptyline extends lifespan in mice.

    “nortriptyline significantly delayed disease onset and extended the lifespan of ALS mice”

    Animalsin ALS mice

    Nortriptyline delays disease onset in models of chronic neurodegeneration

    The European journal of neuroscience1 Aug 2007

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