Normoxia
1 paper3 findings
- 1 lab in 1 country
- Funders: American Heart Association and 3 more
- Animals1
Outcomes
3Right ventricular systolic function
no changein mice1
1 study
Right ventricular systolic function
no changein mice1
Normoxia has no effect on right ventricular systolic function in mice.
“However, HH decreased RV systolic function as assessed by fractional area change (FAC) and stroke volume (SV) that were not rescued with normoxia re-exposure.”
AnimalsNormoxia re-exposure following 4 weeks of hypobaric hypoxia; assessed by fractional area change and stroke volumeright ventricle3 or 6 weeksmale and females
Physiological reports1 Jun 2025
Right ventricular fibrosis
downin mice1
1 study
Right ventricular fibrosis
downin mice1
Normoxia decreases right ventricular fibrosis in mice.
“HH stimulated RV hypertrophy and fibrosis which were attenuated with WK3RR and WK6RR.”
AnimalsFollowing 4 weeks of hypobaric hypoxia to model pulmonary hypertensionright ventricle3 or 6 weeksmale and females
Physiological reports1 Jun 2025
Right ventricular hypertrophy
downin mice1
1 study
Right ventricular hypertrophy
downin mice1
Normoxia decreases right ventricular hypertrophy in mice.
“HH stimulated RV hypertrophy and fibrosis which were attenuated with WK3RR and WK6RR.”
AnimalsFollowing 4 weeks of hypobaric hypoxia to model pulmonary hypertensionright ventricle3 or 6 weeksmale and females
Physiological reports1 Jun 2025