Neferine
- 1 lab in 1 country
- Funder: Japan Society for the Promotion of Science
- Animals1
Outcomes
6Senescence-associated beta-galactosidase
downin animals1
1 study
Senescence-associated beta-galactosidase
downin animals1
Neferine decreases senescence-associated beta-galactosidase.
“oral administration of neferine rejuvenated aging liver tissue, suppressed fatty acid accumulation in the liver, and reduced senescence-associated β-galactosidase activity.”
Animalsaging liver tissueliver
Biological & pharmaceutical bulletin1 Jan 2024
Hepatic fatty acid accumulation
downin animals1
1 study
Hepatic fatty acid accumulation
downin animals1
Neferine decreases hepatic fatty acid accumulation.
“oral administration of neferine rejuvenated aging liver tissue, suppressed fatty acid accumulation in the liver, and reduced senescence-associated β-galactosidase activity.”
Animalsaging liver tissueliver
Biological & pharmaceutical bulletin1 Jan 2024
Fatty acid β-oxidation
upin cells1
1 study
Fatty acid β-oxidation
upin cells1
Neferine increases fatty acid β-oxidation in cells.
“Furthermore, neferine stimulated ATP production and β-oxidation activity in aging cells.”
Cellsaging cells
Biological & pharmaceutical bulletin1 Jan 2024
ATP production
upin cells1
1 study
ATP production
upin cells1
Neferine increases ATP production in cells.
“Furthermore, neferine stimulated ATP production and β-oxidation activity in aging cells.”
Cellsaging cells
Biological & pharmaceutical bulletin1 Jan 2024
Autophagy
upin cells1
1 study
Autophagy
upin cells1
Neferine induces autophagy in cells.
“Pharmacological analyses revealed that neferine-induced autophagy via the death-associated protein kinase 1 (DAPK1) and c-Jun N-terminal kinase (JNK) signaling pathways”
Cellsaging-induced cells
Biological & pharmaceutical bulletin1 Jan 2024
Cellular senescence
downin cells1
1 study
Cellular senescence
downin cells1
Neferine decreases cellular senescence in cells.
“neferine-induced autophagy suppressed the aging phenotype in proliferative and replicative aging-induced cells and aging liver tissue by reactivating mitochondrial function.”
Cellsproliferative and replicative aging-induced cells
Biological & pharmaceutical bulletin1 Jan 2024